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Session: Abstract Breakout Session I Basic Science/Translational

Non-Myeloablative Hematopoietic Cell Transplantation Improves Organ Morphology and Function in a Murine Model of Sickle Cell Disease

Sunday, June 8, 2025
3:15 PM - 3:30 PM ET
Location: Floridian CD
Livestream

Learning Objectives:

  • Upon completion, participant will be able to define non-myeloablative hematopoietic cell transplantation and why is it successful in adult patients with SCD.
  • Upon completion, participant will be able to understand that non-myeloablative hematopoietic cell transplantation can yield mixed donor chimerism and a reversal of the sickle phenotype.
  • Upon completion, participant will be able to understand what non-invasive techniques can be used to evaluate organ pathology.
  • Upon completion, participant will be able to describe how Townes mice mimic the human SCD phenotype.
  • Upon completion, participant will be able to describe how hemolysis and organ function improved in Townes mice post-transplant.