Skip to main content
FSCDR 2025 Annual Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Livestream
Livestream
On Demand
On Demand
Meal
Meal
Ticketed Event
Ticketed Event

Session: Abstract Breakout Session I Basic Science/Translational

Soluble C5b-9 as a Biomarker for Hemolysis-Associated Complications in Sickle Cell Disease

Sunday, June 8, 2025
3:30 PM - 3:45 PM ET
Location: Floridian CD
Livestream

    Presenting Author(s)

  • Emma Pappano

    Medical Student
    University of Illinois Chicago College of Medicine
    Vernon Hills, Illinois, United States

    Slides

    • Co-Author(s)

  • MR

    Maria Armila A. Ruiz, n/a

    Research Associate
    University of Illinois Chicago, Illinois, United States

  • ZI

    Zalaya Ivy, MD, MS

    Assistant Professor
    University of Illinois Chicago, Illinois, United States

  • Santosh L. Saraf, MD

    Associate Professor
    University of Illinois Chicago
    University of Illinois at Chicago
    Chicago, Illinois, United States

Learning Objectives:

  • Better understand the direct relationship between biomarkers of hemolysis and complement activation, as assessed by sC5b-9, in sickle cell disease.
  • Associate hydroxyurea use with lower sC5b-9 concentrations in patients with sickle cell disease.
  • Discuss the association of increased sC5b-9 with tricuspid regurgitant jet velocity > 3 m/sec, a diagnostic marker of pulmonary hypertension and part of the hemolytic-endophenotype of sickle cell disease.