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Session: Abstract Breakout Session I Basic Science/Translational

Altered Resting-State Functional Connectivity in Sickle Cell Disease: Insights into Pain Sensitivity and Cerebral Hemodynamics

Sunday, June 8, 2025
3:45 PM - 4:00 PM ET
Location: Floridian CD
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    Presenting Author(s)

  • Daniel M. Sop, MS, PhD

    Sr. Research Scientist
    Virginia Commonwealth University
    Virginia Commonwealth University
    Richmond, Virginia, United States

    Slides

    • Co-Author(s)

  • YZ

    Yue Zhang, MS

    Research Assistant
    Virginia Commonwealth University, Virginia, United States

  • Wally R. Smith, MD

    Professor
    Virginia Commonwealth University
    Virginia Commonwealth University
    Richmond, Virginia, United States

Learning Objectives:

  • Describe how resting-state functional connectivity (rsFC) differs between adults with Sickle Cell Disease (SCD) and healthy controls, particularly in regions related to pain modulation and cognitive processing.
  • Explain the potential mechanistic link between altered brain connectivity and the dual clinical burden of heightened pain sensitivity and impaired cognition in SCD patients.
  • Identify specific brain regions implicated in disrupted connectivity, and discuss their relevance to therapeutic targeting in SCD-related neurocognitive dysfunction.